Gyrolab Spin Blog

Feb 10, 2015 3:28:00 PM

Latest news from SLAS 2015: Gyrolab xPlore brings new agility to immunoassays

Accelerate every phase of your biopharma development

With the SLAS tagline ‘Come Transform Research’, we feel very much at home at this year’s Annual Conference and Exhibition, especially since we have come to launch a brand new system – Gyrolab xPlore, a smaller companion to Gyrolab xP workstation!

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Topics: Assay Automation, Biomarkers, Pharmacokinetics, Serial sampling, Microsampling


Dec 22, 2014 9:19:00 AM

Of mice and men (and pharmacokinetics)

Knock-in hMICE upgrade value of preclinical models

Of-mice-and-men-(and-pharmacokinetics)George Hu and his colleagues (1) at Pfizer have improved the predictive power of their pharmacokinetic (PK) models by replacing an anti-drug conjugate (ADC) target in mice with the human version, yielding more relevant data from their preclinical study. Their work focused on trophoblast glycoprotein (TPBG), a target of several therapeutic anti-tumor cancer agents currently in the development pipeline. Mice were engineered to express human TPBG. Hu’s group then studied the pharmacokinetics of a clinical-stage anti-TPBG ADC (A1mcMMAF) in wild-type mice and ‘knock-in’ hTPBG mice.

 

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Topics: Pharmacokinetics, Serial sampling, Microsampling


Oct 8, 2014 10:09:00 PM

Test: Award-winning modeling supports 3Rs (Clone)

Non-vivo approach complements microsampling and lean sample analysis

3Rs_reduce_refine_replace_grayThe importance of minimizing animal use was highlighted in the

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Topics: Pharmacokinetics, Serial sampling, Microsampling


Sep 1, 2014 4:44:00 PM

Award-winning modeling supports 3Rs

Non-vivo approach complements microsampling and lean sample analysis

3Rs of responsible research: Reduce, Refine, ReplaceThe importance of minimizing animal use was highlighted in the Nordic Prize for Alternatives to Animal Experiments 2014, awarded at the Digital Health Days conference, held in late August in Stockholm, to Christel Bergström, Maria Karlgren and Pär Matsson at Uppsala University for their contribution of animal-free methods in drug development. The team has used cell models and computer models to study intestinal drug transport, side effects and drug interactions. Using these screening and predictive methods prior to preclinical testing will aid drug design and identify benefits and risks early on, thus reducing animal testing.

 

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Topics: Pharmacokinetics, Serial sampling, Microsampling