Gyrolab Spin Blog: bioprocess

Dec 15, 2015 3:57:00 PM

How to boost clone screening in recombinant therapeutic protein development

High-throughput immunoassays underpin efficiency and productivityHigh-throughput immunoassays underpin efficiency and productivity

Automation is being applied at many levels to power future development of recombinant therapeutic proteins, including screening for the most promising recombinant protein clones. Gregory Keil and co-authors at Merck & Co. have reviewed how this screening can be transformed by combining high-throughput screening methods, analytical techniques and automation to increase capacity, reduce manual operations and risk for error, lower operational costs, and shorten development timelines (see reference).

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Topics: Assay Automation, Bioprocess

Oct 27, 2015 9:14:00 AM

High throughput screening in biologics process development with a minimum of material

Matching scale-down high throughput screening with efficient analytical methods makes the most of precious material

Combining high throughput and small-scale purification methods is a key strategy in bioprocess development. John Welsh and his colleagues at Merck & Co. Inc, USA could develop three orthogonal purification steps using less than 200 mg of a domain antibody fragment, orders of magnitude less than what would typically be required for process development. 


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Topics: Bioprocess, HCP