Gyrolab Spin Blog

Mar 12, 2015 2:29:00 PM

How to find that biologic (without a label)

Label-free biodistribution analysis of human IgG and Fab in mice

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ADME studies are increasingly used to study the in vivo behavior of biologics and the link with therapeutic effects and unwanted side effects. (Bio)Distribution is a critical aspect, but this normally involves tracing radioactively labeled biologics, an approach that has many disadvantages. To meet this challenge, a research group at AstraZeneca used Gyros’ technology to develop a generic method for label-free analysis of the biodistribution and PK of human IgG and Fab fragments in mice.

 

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Topics: Pharmacokinetics, Biodistribution, ADME