Gyrolab Spin Blog

Mar 12, 2015 2:29:00 PM

How to find that biologic (without a label)

Label-free biodistribution analysis of human IgG and Fab in mice


ADME studies are increasingly used to study the in vivo behavior of biologics and the link with therapeutic effects and unwanted side effects. (Bio)Distribution is a critical aspect, but this normally involves tracing radioactively labeled biologics, an approach that has many disadvantages. To meet this challenge, a research group at AstraZeneca used Gyros’ technology to develop a generic method for label-free analysis of the biodistribution and PK of human IgG and Fab fragments in mice.


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Topics: Pharmacokinetics, Biodistribution, ADME