Gyrolab Spin Blog: antibody-drug-conjugate

Sep 7, 2015 10:10:36 AM

ADC + LBA = True

The value and challenges in using ligand-binding assays to analyze Antibody-Drug Conjugates

target_v3Antibody-Drug Conjugates (ADCs) offer great potential in directing therapeutic agents directly to the target, but the complexity of their structure and dynamics in vivo present many bioanalytical challenges. In a recent review article, Seema Kumar and her colleagues at Pfizer Global R&D in the USA present a comprehensive analysis of how Ligand Binding Assays (LBAs) can be used in ADC analysis in preclinical studies.

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Topics: Antibody-Drug Conjugate