Gyrolab Spin Blog

Jan 26, 2016 2:09:46 PM

ADME of therapeutic proteins

Review of critical factors, analytical methods and experimental approaches

adme.pngTherapeutic proteins have revolutionized the treatment of many diseases and have a promising future with more than forty monoclonal antibodies and Fc-fusion therapeutics already on the US market and over 400 more in clinical development stages. Therapeutic proteins are, however, hit hard by a high attrition rate, mainly to poor efficacy, which results in only one in ten making it to market. Increasing the success rate relies on many factors, including the study of absorption, distribution, metabolism and excretion (ADME), as Jay Tibbitts at UCB Celltech, UK, and his coauthors point out in their extensive review on the subject.

 

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Topics: ADME


Mar 12, 2015 2:29:00 PM

How to find that biologic (without a label)

Label-free biodistribution analysis of human IgG and Fab in mice

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ADME studies are increasingly used to study the in vivo behavior of biologics and the link with therapeutic effects and unwanted side effects. (Bio)Distribution is a critical aspect, but this normally involves tracing radioactively labeled biologics, an approach that has many disadvantages. To meet this challenge, a research group at AstraZeneca used Gyros’ technology to develop a generic method for label-free analysis of the biodistribution and PK of human IgG and Fab fragments in mice.

 

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Topics: Pharmacokinetics, Biodistribution, ADME