It’s the Achilles heel of the ligand-binding assay (LBA). That is how matrix effects are described by one author in the Bioanalysis Special Focus Issue, ’Matrix effects in LBAs’. This issue includes valuable editorials and a diverse collection of articles by experts concerning matrix interference, how it affects selectivity, and how it can be reduced. Minimizing interference has many benefits for LBAs, including lower sample dilution, higher sensitivity, and increased robustness.
Minimizing matrix interference with Gyrolab
Gyrolab xP workstation is represented in three articles in this focus issue. The flow-through format of the Gyrolab Bioaffy CD means short contact times that reduce matrix interference.