Inhibitory peptides help identify receptor complex vital to male fertility

Mar 12, 2018 9:00:00 AM

The acrosome reaction is critical for the sperm to penetrate the female egg and fertilize it. Progesterone plays a key role in the acrosome reaction, but how this works has been unclear since spermatozoa lack classical progesterone receptors. Wenming Xu and collaborators at Sichuan University, China, The Chinese University of Hong Kong, and the Australian National University, have shown that the progesterone-induced Ca2+ influx required for the acrosome reaction involves the progesterone receptor or modulator, gamma-aminobutyric acid type A (GABAA) receptor delta subunit (GABRD), in combination with the P2X2 receptor.
The first confirmation that delta subunits were involved in the Ca2+influx came with an experiment that demonstrated that increased intracellular levels of Ca2+ in spermatozoa after progesterone stimulation were suppressed by the δ(392-422) inhibitory peptide but unaffected by a scrambled δ control peptide or a Υ2-peptide.

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Topics: Peptide synthesis, Symphony X peptide synthesizer, Male fertility, The acrosome reaction, Inhibitory peptides

Designer peptoids-improving on Mother Nature

Jul 27, 2017 10:00:00 AM

Peptoids offer a way of improving on nature in a range of biomedical applications such as antimicrobial agents, nanomaterials and diagnosis and treatment of a wide number of cancers.Over 150 peptoid-related papers are now being published per year, and in total, there are over 1700 publications.

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Topics: Peptide synthesis, Peptoids, Symphony X peptide synthesizer