PurePrep Blog - prelude-x

5 factors to consider when choosing a peptide synthesizer

Apr 24, 2019 11:00:00 AM

Choosing a peptide synthesizer to meet your specific needs can be a daunting task. Here are some key factors to consider to be able to synthesize high quality peptides in the number and scale that matches your applications.

1. The question of throughput and parallel synthesis

Different applications and phases of research require different numbers of peptides. A peptide drug discovery program may involve screening hundreds (or even thousands) of peptides to find hits, followed by optimizing structure-activity relationships (SAR) with focused libraries to identify a single candidate that can be advanced to the clinic. The key to success is therefore to choose a synthesizer that has reaction vessels that can deliver the level of parallel synthesis you need to match your application1.

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Topics: Prelude x, Symphony X, Peptide synthesis, Tribute, SPPS, Sonata XT, Real-time UV monitoring

Mapping neuropeptide-receptor and agonist binding: peptide synthesis strategies to guide the design of novel modulators of appetite regulation

May 8, 2018 9:00:00 AM

With 30–70% of adults in the European Union designated overweight and 10–30% obese (WHO), and more than one third of US adults obese (CDC), the global obesity epidemic has stimulated much research into the fundamentals of appetite regulation. Bo Xu and colleagues, based at Uppsala University in Sweden and collaborating with Novo Nordisk A/S in Denmark, have studied the interaction between the agonist neuropeptide Y (NPY) and the human receptor Y2 involved in appetite regulation. Using a combination of computational modeling, peptide chemistry and in vitro pharmacology analysis the research team has gained insight into interactions that promise to guide the design of novel modulators to fight obesity.

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Topics: Prelude x, Peptide synthesis, Obesity, Human neuropeptide Y, NPY, Appetite regulation