Expanding bio-functionality of peptide-based polyelectrolyte complexes through changes in chirality

Jun 9, 2017 8:47:49 AM

In the search for ways to handle soft materials at the nano-level, Polyelectrolyte Complexes (PECs) offer a lot of promise. They self-assemble and their enormous diversity of structure and chemical composition enable functionality to be fine-tuned. The biocompatibility and biodegradability of peptide polymer PECs means they are particularly useful in such as food additive encapsulation, micellar drug delivery, and scaffolding cell growth for tissue engineering. The physical properties of peptide polymer PECs can be modulated based on many factors. Naomi Pacalin, Lorraine Leon, and Matthew Tirrell at the University of Chicago, USA, have shown that changing the chirality of peptide polymer PECs alters the strength of polymer chain interactions, allowing chirality to be used to tailor polymers to have the precise properties needed for a particular application (Eur. Phys. J. Spec. Top., 2016, 225:1805).

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Topics: Peptide synthesis, PS3 peptide synthesizer, peptide-based polyelectrolyte complexes